BioGaia Protectis Baby Drops -- Best Overall
BioGaia Protectis Baby Drops contain Lactobacillus reuteri DSM 17938, one of the most researched probiotic strains in infant gut health. Studies have shown this strain can reduce crying time in colicky babies and support more regular bowel movements. The oil-based formula mixes easily into breast milk or formula, and the 10 mL bottle lasts about a month at the standard five-drop daily dose. Parents consistently note softer stools within a few days of starting use. The dropper applicator makes dosing clean and straightforward. This is the most clinically backed choice on this list and a reliable starting point for most parents.
Check price on Amazon →Find the safest constipation relief for babies in 2026. These five pediatrician-recommended picks offer gentle, effective support without harsh stimulants or unnecessary additives.
Health disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult your pediatrician before giving any supplement or remedy to an infant or young child.
Infant constipation is one of the most common concerns new parents face, especially during transitions like introducing formula or solid foods. The right product can bring quick, gentle relief without disrupting your baby’s developing digestive system. The five picks below cover the most trusted categories, from probiotic drops to gentle fiber syrups.
| Product | Best For | Rating |
| — | — | — |
| BioGaia Protectis Baby Drops | Breastfed and formula-fed infants | 4.8/5 |
| Mommy’s Bliss Gripe Water | Gas and mild constipation relief | 4.6/5 |
| Little Remedies Tummy Relief | Fast-acting gas drops | 4.5/5 |
| Enfamil Reguline Formula | Formula-fed babies prone to hard stools | 4.7/5 |
| Gerber Soothe Probiotic Drops | Colic and irregular bowel movements | 4.6/5 |
How we evaluated these
We compare every pick against the field on real specifications, certifications, and aggregated owner reviews. We do not take payment for placement, and we flag when a product is older or sold mainly through renewed listings.
The shortlist
| Pick | Best for | Score | |
|---|---|---|---|
| BioGaia Protectis Baby Drops -- Best Overall | Check price | ||
| Mommy's Bliss Gripe Water -- Best Budget Pick | Check price | ||
| Little Remedies Tummy Relief Drops -- Best for Gas-Related Constipation | Check price | ||
| Enfamil Reguline Formula -- Best for Formula-Fed Babies | Check price | ||
| Gerber Soothe Probiotic Drops -- Best Combo (Colic + Constipation) | Check price |
Each pick, examined
BioGaia Protectis Baby Drops -- Best Overall
BioGaia Protectis Baby Drops contain Lactobacillus reuteri DSM 17938, one of the most researched probiotic strains in infant gut health. Studies have shown this strain can reduce crying time in colicky babies and support more regular bowel movements. The oil-based formula mixes easily into breast milk or formula, and the 10 mL bottle lasts about a month at the standard five-drop daily dose. Parents consistently note softer stools within a few days of starting use. The dropper applicator makes dosing clean and straightforward. This is the most clinically backed choice on this list and a reliable starting point for most parents.
Mommy's Bliss Gripe Water -- Best Budget Pick
Mommy's Bliss Gripe Water is a longtime staple in baby medicine cabinets, and its 2026 formula remains free of alcohol, parabens, and artificial flavors. The ginger and fennel blend helps relax the digestive tract, easing gas and the bloating that often accompanies constipation. For a 4 oz bottle, it is one of the most affordable options available. It works best for occasional, mild constipation rather than chronic cases. Many parents keep it on hand as a first response before escalating to other remedies. The measured syringe included in the box makes dosing accurate for infants from two weeks old and up.
Little Remedies Tummy Relief Drops -- Best for Gas-Related Constipation
Little Remedies Tummy Relief Drops use simethicone to break up gas bubbles in the digestive tract. While simethicone targets gas more directly than constipation itself, many cases of infant discomfort and straining are gas-related rather than true constipation. The unflavored formula is easy to administer before or after feeding and has a strong safety profile with no known drug interactions. The small 1 oz bottle is portable and shelf-stable, making it convenient for travel or daycare bags. For parents who suspect trapped gas is the root cause of their baby's distress, this is a focused and affordable fix.
Enfamil Reguline Formula -- Best for Formula-Fed Babies
Enfamil Reguline is designed specifically for formula-fed infants who experience chronically hard, difficult-to-pass stools. Its blend of prebiotics (70% GOS / 30% PDX) promotes a softer stool consistency by feeding beneficial gut bacteria. Unlike single-dose remedies, Reguline works as a complete infant formula replacement, so its effects are ongoing rather than situational. Most parents report a noticeable difference within a week of switching. It is available in both powder and ready-to-feed formats. If your baby is fully formula-fed and struggles with constipation regularly, transitioning to Reguline is one of the most comprehensive approaches available without a prescription.
Gerber Soothe Probiotic Drops -- Best Combo (Colic + Constipation)
Gerber Soothe Probiotic Drops contain L. reuteri in a sunflower oil base, similar to BioGaia but at a slightly lower price point. They are designed to address both colic and irregular bowel movements, making them a versatile option when parents are dealing with multiple digestive symptoms at once. The bottle provides a 30-day supply at the recommended daily dose, and the tasteless formula is easy to add to any feeding. Gerber's formulation is third-party tested for potency and purity. For parents who want a dual-action approach without committing to the higher cost of BioGaia, Gerber Soothe offers solid value.
Buying considerations
What to consider
Start by identifying the likely cause. If your baby is breastfed, constipation is rare before solids are introduced, and the issue may resolve with dietary changes on the parent's end. Formula-fed babies may benefit from switching to a prebiotic-enriched formula like Enfamil Reguline. For occasional constipation in infants over two weeks, gripe water or probiotic drops are a low-risk first step. Avoid any remedy containing laxatives, sorbitol, or herbal stimulants unless directed by a pediatrician. When constipation is accompanied by vomiting, blood in the stool, or significant weight loss, stop home remedies and see a doctor immediately.
What to consider
Baby constipation products overlap with broader digestive care. If you are looking for related support, see our guides on [best probiotic supplements for kids](/articles/best-probiotic-supplement-for-kids) and [best baby formula for sensitive stomachs](/articles/best-baby-formula-for-sensitive-stomachs). Our [testing methodology](/methodology) explains how we evaluate infant health products.
Questions answered
Signs include fewer than three bowel movements per week, hard or pellet-like stools, straining or crying during a bowel movement, and a firm or bloated belly. Formula-fed babies tend to go less frequently than breastfed babies, so frequency alone is not the only indicator. Always consult your pediatrician if you are unsure.
Most probiotic drops designed for infants are considered safe from birth, but you should confirm with your pediatrician before starting any supplement for a newborn. Look for products containing Lactobacillus reuteri or Bifidobacterium infantis, which are the strains most studied in infants and have a strong safety record in clinical research.
