Biotrue Multipurpose Solution -- Best Overall for Dry Eyes
Biotrue is formulated to match the biology of the eye. It uses hyaluronan (HA), a naturally occurring lubricant found in tears, as its conditioning agent. It also maintains a pH matched to healthy tears and contains a dual disinfectant system that keeps the formula effective without the irritating agents found in older solutions. For dry eye wearers, the HA conditioning coat deposited on the lens overnight provides measurable end-of-day comfort improvements over standard solutions. Bausch + Lomb designed this for use with both standard hydrogel and silicone hydrogel lenses.
Check price on Amazon →The right multipurpose solution can make a real difference for dry eye lens wearers. These five are formulated with extra conditioners to keep lenses comfortable.
Not all contact lens solutions are equal when it comes to dry eye comfort. The conditioning step is where moisture agents are deposited on the lens, so choosing a solution with strong humectant technology pays off throughout the wear day. Here are five solutions that stand out for dry eye suitability.
Health note: If dry eye symptoms persist or worsen despite changing solutions, see an eye care professional. Chronic dry eye can have underlying causes that require treatment beyond lens care products.
| Product | Best For | Rating |
| — | — | — |
| Biotrue Multipurpose Solution | Biomimetic formula, daily comfort | 4.8/5 |
| Opti-Free Puremoist | Silicone hydrogel wearers | 4.7/5 |
| Alcon Clear Care Plus with HydraGlyde | Deep cleaning + moisture | 4.6/5 |
| Bausch + Lomb renu Advanced | Budget-friendly moisture focus | 4.5/5 |
| iSi Sensitive Eyes Plus | Sensitive, allergy-prone eyes | 4.3/5 |
How we test
We compare every pick against the field on real specifications, certifications, and aggregated owner reviews. We do not take payment for placement, and we flag when a product is older or sold mainly through renewed listings.
At a glance
| Pick | Best for | Score | |
|---|---|---|---|
| Biotrue Multipurpose Solution -- Best Overall for Dry Eyes | Check price | ||
| Opti-Free Puremoist -- Best for Silicone Hydrogel Lenses | Check price | ||
| Alcon Clear Care Plus with HydraGlyde -- Best for Deep Cleaning and Moisture | Check price | ||
| Bausch + Lomb renu Advanced -- Best Budget Moisture Solution | Check price | ||
| iSi Sensitive Eyes Plus -- Best for Sensitivity-Prone Wearers | Check price |
The picks, reviewed
Biotrue Multipurpose Solution -- Best Overall for Dry Eyes
Biotrue is formulated to match the biology of the eye. It uses hyaluronan (HA), a naturally occurring lubricant found in tears, as its conditioning agent. It also maintains a pH matched to healthy tears and contains a dual disinfectant system that keeps the formula effective without the irritating agents found in older solutions. For dry eye wearers, the HA conditioning coat deposited on the lens overnight provides measurable end-of-day comfort improvements over standard solutions. Bausch + Lomb designed this for use with both standard hydrogel and silicone hydrogel lenses.
Opti-Free Puremoist -- Best for Silicone Hydrogel Lenses
Opti-Free Puremoist from Alcon uses their HydraGlyde Moisture Matrix, a polymer technology that adheres to silicone hydrogel lens surfaces and maintains moisture throughout the day. Many dry eye wearers who switched from older Opti-Free formulas or from competing brands report a noticeable improvement in end-of-day comfort. The disinfection efficacy is strong, meeting FDA standards for the pathogens that matter most in contact lens care. This is the solution Alcon pairs with their own Air Optix lens line, which is a meaningful endorsement of compatibility.
Alcon Clear Care Plus with HydraGlyde -- Best for Deep Cleaning and Moisture
Clear Care Plus is a hydrogen peroxide-based system rather than a traditional multipurpose solution. It provides a deeper clean than MPS options, breaking down protein deposits more effectively. The Plus version adds HydraGlyde to restore moisture during the neutralization step. The tradeoff is the six-hour neutralization requirement in the provided case; you cannot rinse and wear immediately. For wearers who have lens dryness tied to protein build-up, this combination of thorough cleaning and moisture restoration is hard to beat.
Bausch + Lomb renu Advanced -- Best Budget Moisture Solution
renu Advanced uses a triple-action formula combining a lubricant, conditioner, and disinfectant in one step. For the price, it delivers a solid moisture profile, noticeably better than the basic renu Fresh formula for dry eye wearers. It is compatible with a wide range of soft lens types and is available at most pharmacies. Not quite at the level of Biotrue or Opti-Free Puremoist for persistent dry eye discomfort, but a strong performer for mild dryness at a lower price point.
iSi Sensitive Eyes Plus -- Best for Sensitivity-Prone Wearers
Sensitive Eyes Plus uses a low-preservative formula that is gentler on eyes that react poorly to higher-concentration disinfectant systems. It is not the most powerful cleaner available, but the reduced preservative load makes it worth considering for dry eye wearers whose irritation is at least partly driven by solution chemistry. The conditioning component provides basic moisture without the advanced polymer systems of Biotrue or Puremoist. Pair with preservative-free rewetting drops during the day for best results with this solution.
What to look for
What to consider
Look for solutions with identified moisture agents on the label. Hyaluronic acid (hyaluronan), polyvinyl pyrrolidone (PVP), and poloxamine-based conditioners are the most commonly used and best-evidenced lubricants in lens solutions. Avoid solutions that list only saline and a preservative with no conditioning ingredient.
What to consider
Consider your cleaning needs separately from moisture. If you have heavy protein deposits at end of day, a hydrogen peroxide system like Clear Care Plus will clean more thoroughly but requires planning for the neutralization time. For most wearers, a well-formulated MPS is sufficient.
What to consider
Brand-specific compatibility matters more with silicone hydrogel lenses than with standard hydrogel. Check the lens manufacturer's website for recommended solution pairings.
What to consider
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What to consider
For daytime relief in addition to an improved storage solution, see our guide to [best contact lens rewetting drops](/articles/best-contact-lens-rewetting-drops). For lens selection targeting dry eyes, check [best contact lenses for dry eyes](/articles/best-contact-lens-for-dry-eyes). All evaluation criteria are on the [methodology page](/methodology).
FAQs
Yes, the conditioning agents in a multipurpose solution coat the lens surface when you store your lenses overnight. High-quality moisture-focused solutions deposit lubricating polymers on the lens that persist during wear, providing a more comfortable starting point each morning. Solutions with hyaluronic acid or similar humectants are especially beneficial for dry eye wearers.
Most multipurpose solutions are marketed as universal, but formulations differ significantly in their lubricating additives. Solutions designed specifically for dry eye discomfort typically contain hyaluronic acid, PVP, or similar moisture-binding agents. Always verify that a solution is approved for your specific lens type, as some silicone hydrogel lens brands recommend particular solutions for best compatibility.
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